BioShock is a FPS RPG hybrid that was released in 2007, and had a lot of commentary about Ayn Rand philosophy, the nature or nurture argument and morality. It also featured the ability to set freeze people and explode their corpses with a grenade launcher. More importantly, it features an awful of pseudo-science...
The Set-Up
You, as a feller called Jack, go under the sea to a fallen utopia called Rapture. Whilst there, you make use of the miracle substance ADAM, which is a form of unstable stem cells produced by a certain species of sea slug. Using ADAM allows you to modify your genetic code using Plasmids, which give you a range of new abilities. These include making you more resilient to damage, or letting bees live in your forearms, then shooting them out as a buzzing bullet of pain.